ABSTRACT
Objectives: In support with field cancerization theory, some patients with lung cancer [LC] will also have synchronous invasive or pre-invasive bronchial lesions. In this cross sectional - analytic study autofluorescence bronchoscopy [AFB] was used to assess the prevalence of synchronous lesions in patients with LC
Materials and methods: All patients with abnormal sputum cytology underwent white light and AFB. From 335 patients with abnormal sputum cytology referred for AFB, lung cancer was detected in 91 patients [89 male and 2 female] of age [mean +/- SD], 67 +/- 8 years. 77 had squamous cell carcinoma [SqCC], 13 had adenocarcinoma and one patient with small cell lung cancer [SCLC]
Results: Synchronous lesions detected in 26 [29%] patients, 25 [33%] of patients with SqCC, one with adenocarcinoma, no synchronous lesion detected in one patient with SCLC. The most severe detected synchronous lesion was adenocarcinoma in one patient, Carcinoma insitu [CIS] in 4 patients, severe dysplasia in 3 patients, moderate dysplasia in 10 patients, and mild dysplasia in 8 patients. Synchronous lesions were more frequently detected in current smokers [35%], than in ex-smokers [20%] and non-smokers [15%]
Conclusion: Synchronous preinvasive lesions are frequent in patients with LC and AFB should be included in pre-operative evaluation of these patients
Subject(s)
Humans , Male , Female , Bronchial Neoplasms , Bronchoscopy/methods , Sputum/cytologyABSTRACT
This study was to evaluate the effects of interferon of alpha- 2 bon the development of submandibular salivary glands of co-1 mice neonates. Twenty adult female and ten adult male alboi mice [cd-1] of average weight 110-120gm were used in this study. They were divided into 2 groups, ten females and five males each, group, [control] inject by 0.1ml of sterile water subcutaneously three times per week, two weeks before breeding and during pregnancy, group II [experimental] injected by the same way as control by recombinant human interferon alpha -2b by dose of 10.000iu in .1 ml sterile water. Histological examination of the developing submandibular salivary glands reveled retardation in development, indistinct cell boundaries of acini and ducts as well as some acini have lost nuclei and appear as a homogenous mass due to atrophic and degenerative changes. The photochemical results showed an increased content and concentration of both neutral mucosubstances and acid mucopolysaccharides in experimental group than those noted in control group from these results it is conceivably to conclude that the interferon alpha- 2b, in prolonged duration of treatment lead to harmful effect on developing salivary glands